Statins help stop your liver from making as much cholesterol, including LDL. Usual Adult Dose of Repatha for Hyperlipidemia: -140 mg subcutaneously every 2 weeks, or Repatha isn’t known to interact with other medications. Repatha is also used to help lower the risk of stroke, heart attack, or other heart complications in people with heart or blood vessel problems caused by plaque build-up or hardening in the arteries (also called atherosclerosis, or arteriosclerosis). It may also be used with other drugs that lower your cholesterol, such as a statin. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. For the single-use, on-body infuser plus prefilled cartridge, this should be done at least 45 minutes before use. However, it…, High cholesterol levels can increase a person’s risk of heart disease. Throw away after one use, even if there is still some medicine left inside. Use the medicine within 30 days if it is kept at room temperature. If you have questions about reducing plaque in your arteries, talk with your doctor. PCSK9 inhibitors, on the hand, help your body get rid of cholesterol by blocking a certain protein in your liver that allows cholesterol to build up in your blood. Any part of the drug that isn’t used within 30 days should be thrown away. High cholesterol occurs when you have more cholesterol in your blood than your body needs. Biosimilar drugs are made to treat the same conditions as the parent drug. While wearing the on-body infusor, you may perform moderate activities such as walking, bending, or reaching. This can include setting an alarm on your phone or downloading a reminder app. bruising, pain, or redness at the injection site, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 8.1% of people who took Repatha developed diabetes, 7.7% of people who took a placebo developed diabetes, 5% of people who took Repatha plus a statin drug had a muscle-related side effect, 4.8% of people who took a placebo plus a statin drug had a muscle-related side effect, 3% to 6.1% of people who took Repatha had gastroenteritis, depending on the condition treated, 0% to 2% of people who took a placebo had gastroenteritis, depending on the condition treated, the type and severity of the condition you’re using Repatha to treat, your preference for the size of your Repatha dose, your preference for how often you want to receive your Repatha dose, 140 mg given by subcutaneous injection every 2 weeks, 420 mg given by subcutaneous injection once every month, using the Pushtronex system to inject a prefilled cartridge over 5 minutes, using the SureClick autoinjector or prefilled syringe to give three consecutive injections within 30 minutes, 140 mg by subcutaneous injection every 2 weeks, 420 mg by subcutaneous injection once a month. A biosimilar is very similar version of the parent biologic drug, but it’s not identical. Do not use an injection device that has been dropped onto a hard surface, even if you cannot see a break in it. If you’re using the prefilled syringe or the prefilled SureClick autoinjector, allow it to warm for at least 30 minutes before using it. Repatha belongs to a class of medications called PCSK9 inhibitors. For more information about your treatment options, talk with your doctor. If you’re not sure if you’ll need to get prior authorization for Repatha, contact your insurance company. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Elimination of Repatha is primarily through a proteolytic pathway not susceptible to saturation. heart attack, stroke, death from cardiovascular disease, hospitalization for unstable angina and certain types of heart surgery occurred at a rate of 4.5 per 100 patient years in people received Repatha. A generic drug, by contrast, is an exact copy of a brand-name drug that’s made from chemicals. Repatha belongs to a class of medications called PCSK9 inhibitors. Do not freeze. Skip the missed dose if you are more than 7 days late for the injection. Some of the people didn’t have diabetes when the study began. Repatha belongs to a class of medications known as PCSK9 inhibitors. If you have questions about using Repatha with other drugs, talk with your doctor or pharmacist. If you have questions about the differences between Repatha and statin drugs, talk with your doctor. For example, this may happen if you’re traveling and accidentally leave the drug at home. Here’s some detail on certain side effects this drug may or may not cause. To learn about other mild side effects, talk with your doctor or pharmacist, or view Repatha’s Patient Information. It may take up to 15 seconds to inject this medicine using a prefilled syringe or a SureClick autoinjector. Dropping an injection device can cause it to break. If you need financial support to pay for Repatha, or if you need help understanding your insurance coverage, help is available. Repatha can cause mild or serious side effects. You will need to wear the device for about 9 minutes to get the full dose. Evolocumab (trade name Repatha) is a monoclonal antibody medication designed for the treatment of hyperlipidemia. Your insurance company may require you to use a specialty pharmacy to get Repatha. Prior to administering Repatha, allow the drug to warm at room temperature (68°F to 77°F/20°C to 25°C). In addition, no clinical studies of Repatha have involved lactating animals. Instead, use a new Repatha dose. Repatha products should be visually checked for any particles or discoloration before use. Repatha and Crestor have different FDA-approved uses, but they’re both used to: These drugs haven’t been directly compared in clinical studies. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. You’ll use Repatha at home after your doctor trains you or your caregiver on how to give the injections. People who were assigned to get Repatha received either 140 mg every 2 weeks or 420 mg once a month. These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries. Call your doctor for medical advice about side effects. However, statins can also cause other side effects, including joint pain, pancreatitis, and rhabdomyolysis (a serious condition that breaks down muscle tissue). If you have concerns about hair loss during your treatment, talk with your doctor. Treatment for: High Cholesterol; Prevention of Heart Attack and Stroke Repatha … The results showed that: Muscle pain is also a possible side effect of statin drugs. When someone experiences…, © 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. For this purpose, Repatha is used along with a healthy diet and other LDL-lowering treatments. Repatha and Crestor are prescribed for similar uses. Below are examples of these side effects. The estimated effective half-life is 11 to 17 days. Do not use more Repatha than your doctor recommends. together with diet, treating primary hyperlipidemia (including heterozygous familial, together with diet, treating homozygous familial hypercholesterolemia (HoFH) in adults and children, using the single-use, on-body infuser to inject a prefilled cartridge over 5 minutes, giving three consecutive injections within 30 minutes, using the single-use prefilled autoinjector or prefilled syringe. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This program includes access to the Repatha Copay Card, which may help lower the cost of the drug for you. Repatha is also FDA-approved to lower LDL (“bad”) cholesterol in adults and children with a condition called homozygous familial hypercholesterolemia (HoFH). If you’re taking Repatha once a month, go ahead and take your missed dose, even if it’s been more than 7 days. Follow any state or local laws about throwing away used needles and syringes. Call your doctor right away if you have serious side effects. As with all medications, the cost of Repatha can vary. To help make sure you don’t miss a dose, try using a medication reminder. What you should do depends on the Repatha dose your doctor prescribes. This could include ezetimibe (Zetia) and statins such as Lipitor or Crestor. Repatha and Crestor have some similar side effects and other that vary. Regulators approved a new type of cholesterol-lowering drug aimed at millions of people who can't tolerate statins. This drug hasn’t been studied during pregnancy.