Understanding the pathophysiology and successful treatment for ALD is closely associated with the suitability of the animal model, which fully reflects all aspects of the pathogenesis and typical histological findings. However, you need some fat to help absorb the fat-soluble vitamins A, D, E and K. Focus on heart-healthy unsaturated fats such as those found in nuts, avocados and olive oil. If you have a liver problem, you should be aware that liver disease is ignored by almost all diet plans. Fat buildup in the liver that is not due to alcohol consumption, also known as non-alcoholic fatty liver disease, affects 20-30% of adult populations in developed countries. The reason is that it is mostly symptom free and there are no treatments so most of the research has been on heart and diabetes issues. Non-alcoholic fatty liver disease is strongly associated with obesity. Alcoholic liver disease (ALD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. Insulin resistance means that the pancreas has to produce more insulin in order to maintain normal blood glucose levels, and is the first step towards developing diabetes. If you are concerned about your liver you are part of an ignored patient group. Excess fat causes insulin resistance and inflammatory signals. It is the major cause of liver disease in Western countries. The combination of too much fat, too much sugar, and too little exercise is the best way become obese — in the liver. A high-fat diet can worsen liver disease and cause fatty liver in people without liver disease. Alcoholic liver disease (ALD), also called alcohol-related liver disease (ARLD), is a term that encompasses the liver manifestations of alcohol overconsumption, including fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.. Non-alcoholic fatty liver disease (NAFLD) is characterized by the abnormal accumulation of fat within the liver. Journal of Hepatology 2016: Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications [overview article; ungraded] Diabetes Care 2018: Nonalcoholic fatty liver disease and risk of incident type 2 diabetes: A meta-analysis [systematic review of observational studies with HR >2; weak evidence] ↩